What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice

Medientyp: Buch

Titel: What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice

Enthält: Designer mice : scope and sourcebooks -- Of unicorns and chimeras : how to generate a transgenic or knockout mouse for behavioral phenotyping -- General health : give your mouse a physical -- Motor functions : open field, holeboard, rotarod, balance, grip, circadian activity, circling, stereotypy, ataxic gait, seizures -- Sensory abilities : olfaction, vision, hearing, taste, touch, nociception -- Learning and memory : Morris swim task, spatial mazes, cued and contextual conditioning, conditioned taste aversion, conditioned eyeblink, olfactory discrimination, social recognition, passive avoidance, schedule controlled operant tasks, motor learning, attention -- Feeding and drinking : daily consumption, restricted access, choice tests, microstructural analysis -- Reproductive behaviors : sexual and parental behaviors -- Social behaviors : social interaction, nesting, grooming, juvenile play, aggression -- Emotional behaviors : animal models of psychiatric disorders : mouse models of fear, anxiety, depression, schizophrenia -- Reward : self-administration of addictive drugs, conditioned place preference -- Neurodevelopment and neurodegeneration : assaying behaviours in infant, juvenile, and aged mice -- Putting it all together : choice of tests, order of testing, number of mice, equipment, housing and testing environment -- The next generation : conditional and inducible mutations, viral vector gene delivery, RNA silencing, quantitative trait loci analysis, DNA microarrays, chemical mutagenesis, gene therapy, ethical issues

Beteiligte: Crawley, Jacqueline N. [VerfasserIn]

Erschienen: Hoboken, NJ: Wiley, c 2007

Ausgabe: 2. ed.

Umfang: XVI, 523 S.; Ill., graph. Darst

Sprache: Englisch

ISBN: 9780471471929

RVK-Notation: WG 3450 : Gentechnologie, Transgene Organismen

Schlagwörter: Maus > Transgene Tiere > Verhalten > Phänotyp
Knockout

Entstehung:

Anmerkungen: Literaturverz. S. 383 - 501

What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice - [2. ed.]

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