• Medientyp: Buch
  • Titel: A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery
  • Beteiligte: Goodnow, Robert A. [Hrsg.]
  • Erschienen: Hoboken, NJ: Wiley, 2014
  • Enthält:
  • Umfang: XXV, 453 S., [8] Bl; Ill., graph. Darst
  • Sprache: Englisch
  • ISBN: 9781118832691; 9781118487686; 1118487680
  • Entstehung:
  • RVK-Notation: VS 5350 : Allgemeines
  • Schlagwörter: Arzneimittelforschung > Genbibliothek > Kombinatorische Synthese
    Molekülbibliothek > Genbibliothek > Kombinatorische Synthese > Arzneimittelforschung > Arzneimittelentwicklung
  • Beschreibung: Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology
  • Anmerkungen: Includes bibliographical references and index

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  • Status: Ausleihbar